Have you ever dreamed of becoming the best version of yourself? The unique drug “Substance” will make you younger, more beautiful, more perfect. The fame of Hollywood star Elizabeth Sparks (Demi Moore) is a thing of the past, though she still hosts a popular fitness show on television. But when her show is about to be relaunched with a new star, Elizabeth decides to take on Substance. Thus, the young and sexy Sue (Margaret Quolli) is born. Perfection has its price, however, and payback won’t be long in coming….